The Mustangs offense rolled early, piecing together an 80-yard drive capped with a 28-yard David Mahr touchdown reception for the first possession of the game.
Thirty-eight points, 293 yards and three Mustang turnovers later, Cal Poly would answer back.
Weber State added a field goal and junior quarterback Cameron Higgins’ fourth touchdown pass to complete the offensive showcase.
Toone finished the regular season with his 200th career catch and 28th career touchdown. He had 11 catches for 176 yards against the Mustangs.
Cal Poly’s leaders offensively were Jake Romanelli with 55 yards rushing on 15 carries and Smith, who completed 11 of 24 passes for 166 yards and both Mustang touchdowns. He was sacked five times and threw a pair of interceptions.
Mahr, Hall, Eric Gardley and Grayson each had a pair of catches for Cal Poly.
Junior linebacker Marty Mohamed recorded eight tackles and senior cornerback Xavier Gardner added seven for Cal Poly.
For Weber State, Higgins completed 23 of 33 passes. He passed for 399 yards and two scores in a 49-35 win over the Mustangs in last year’s first-round NCAA Football Championship Subdivision playoff game.
This season Cal Poly’s rushing attack ran through defenses for 1,963 yards and the Mustang passing threat contributed for 1,686 yards.